FastLane™ Structure Libraries
X-ray crystallography services at SARomics Biostructures are run at our cutting-edge, high-throughput pipeline anchored by our FastLane™ Premium and FastLane™ Standard libraries.
FastLane™ Premium Structures
Library of verified drug targets that have already been expressed, purified, and crystallized at the company (off-the-shelf structures). Purified proteins are available for the immediate start of a project.
FastLane™ standard
Library of verified drug targets for which expression plasmids and protocols for expression, purification, and crystallization are available at the company.
FastLane™ Structures Libraries of Proteins and constructs
Our FastLane™ Premium and FastLane™ Standard libraries boast 500+ verified drug targets ready to be directly crystallized with your chosen ligand (FastLane™ Premium) or expressed, purified, and crystallized according to verified protocols (FastLane™ Standard) within a few weeks.
Please find below the details of our FastLane™ Premium and FastLane™ Standard libraries of off-the-shelf drug-target proteins. To explore the experimental details of our X-ray crystallography technology platform, please visit our methods and technologies knowledge center.
SARomics Biostructure’s X-ray crystallography services are leveraged by our location close to the MAX IV Laboratory in Lund, one of the most advanced synchrotron radiation facilities in the world.
the FastLane™ Standard Library
The FastLane™ Standard library currently contains around 500 constructs of drug target proteins ready for expression, purification, crystallization, and X-ray crystallographic structure determination according to verified protocols. The library includes a large number of protein kinases, phosphatases, epigenetic factors, and many other drug targets. Using our high-throughput protein X-ray crystallography pipeline, the turnaround time for structure determination for these proteins is between 6 to 12 weeks (depending on the protein).
How to search the table
The table can be serched by individual protein name or a whole protein family. For example, entering “kinase” in the search field will return a list of all kinases in the library. The protein families with largest number of entries in the library may be found using the search terms amino acid metabolic enzyme, phosphatase, bromodomain, epigenetic targets, oxidoreductase, ATPase, GTPase, nucleotide metabolism, BTB-Kelch, transferase, G-protein regulator, lipid signalling, PDZ domain, phosphoinositide dependent signalling, transferase and hydrolase.
GeneProtein name | UniProt ID | Sequence range | Protein family | PDB ID
| |
---|---|---|---|---|---|
AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 | O43865 | 89-530 | amino acid metabolic enzymes | 3MTG |
AHCYL2 | Adenosylhomocysteinase 3, NAD binding domain | Q96HN2 | 175-607 | amino acid metabolic enzymes | 3GVP |
ASS1 | Argininosuccinate synthase | P00966 | 1-412 | amino acid metabolic enzymes | 2NZ2 |
CSAD | Cysteine sulfinic acid decarboxylase | Q9Y600 | 1-493 | amino acid metabolic enzymes | 2JIS |
CTH | Cystathionine gamma-lyase | P32929 | 1-402 | amino acid metabolic enzymes | 2NMP/3COG |
GLUL | Glutamine synthetase | P15104 | 5-365 | amino acid metabolic enzymes | 2OJW |
GPT2 | Alanine aminotransferase 2 | Q8TD30 | 49-523 | amino acid metabolic enzymes | 3IHJ |
MPST | 3-mercaptopyruvate sulfurtransferase | P25325 | 11-289 | amino acid metabolic enzymes | 3OLH |
PCYT2 | Ethanolamine-phosphate cytidylyltransferase | Q99447 | 18-356 | amino acid metabolic enzymes | 3ELB |
PSAT1 | Phosphoserine aminotransferase | Q9Y617 | 17-370 | amino acid metabolic enzymes | |
SCLY | Selenocysteine lyase | Q96I15 | 8-445 | amino acid metabolic enzymes | 2HDY/3GZC/3GZD |
TAT | Tyrosine aminotransferase | P17735 | 41-444 | amino acid metabolic enzymes | 3DYD |
GFPT1 | Glutamine–fructose-6-phosphate aminotransferase [isomerizing] 1, isomerase domain | Q06210 | 332-649 | Aminotransferas | 2V4M |
BIRC3 | Baculoviral IAP repeat-containing protein 3, BIR domain | Q13489 | 242-337 | Apoptosis-Inflammation Domains | 2UVL |
NAIP | Baculoviral IAP repeat-containing protein 1, BIR2 domain | Q13075 | 139-244 | Apoptosis-Inflammation Domains | 2VM5 |
ALOX12 | Polyunsaturated fatty acid lipoxygenase | P18054 | 172-663 | Arachidonic acid metabolism | 3D3L |
PTGDS | Prostaglandin-H2 D-isomerase | P41222 | 23-190 | Arachidonic acid metabolism | 2WWP |
FIGNL1 | Fidgetin-like protein 1 | Q6PIW4 | 341-674 | ATPases – AAA | 3D8B |
NVL | Nuclear valosin-containing protein-like | O15381 | 573-845 | ATPases – AAA | 2X8A |
SPG7 | Paraplegin | Q9UQ90 | 305-565 | ATPases – AAA | 2QZ4 |
DDX10 | Probable ATP-dependent RNA helicase | Q13206 | 47-280 | ATPases – DExD-DExH RNA helicases | 2PL3 |
DDX18 | ATP-dependent RNA helicase | Q9NVP1 | 149-387 | ATPases – DExD-DExH RNA helicases | 3LY5 |
DDX19B | ATP-dependent RNA helicase | Q9UMR2 | 54-475 | ATPases – DExD-DExH RNA helicases | 3EWS/3G0H |
DDX20 | Probable ATP-dependent RNA helicase | Q9UHI6 | 41-268 | ATPases – DExD-DExH RNA helicases | 2OXC/3B7G |
DDX25 | ATP-dependent RNA helicase | Q9UHL0 | 307-479 | ATPases – DExD-DExH RNA helicases | 2G2J/2RB4 |
DDX3X | ATP-dependent RNA helicase | O00571 | 168-352 | ATPases – DExD-DExH RNA helicases | 2I4I |
DDX41 | Probable ATP-dependent RNA helicase DDX41 | Q9UJV9 | 402-569 | ATPases – DExD-DExH RNA helicases | 2P6N |
DDX47 | Probable ATP-dependent RNA helicase | Q9H0S4 | 5-230 | ATPases – DExD-DExH RNA helicases | 3BER |
DDX5 | Probable ATP-dependent RNA helicase | P17844 | 68-307 | ATPases – DExD-DExH RNA helicases | 3FE2 |
DDX52 | Probable ATP-dependent RNA helicase | Q9Y2R4 | 139-381 | ATPases – DExD-DExH RNA helicases | 3DKP |
DDX53 | Probable ATP-dependent RNA helicase | Q86TM3 | 204-430 | ATPases – DExD-DExH RNA helicases | 3IUY |
DHX9 | ATP-dependent RNA helicase A | Q08211 | 329-563 | ATPases – DExD-DExH RNA helicases | 3LLM |
EIF4A1 | Eukaryotic initiation factor 4A-I | P60842 | 20-238 | ATPases – DExD-DExH RNA helicases | 2G9N |
IFIH1 | Interferon-induced helicase C domain-containing protein 1 | Q9BYX4 | 277-490 | ATPases – DExD-DExH RNA helicases | 3B6E |
HSPA1A | Heat shock 70 kDa protein 1A | P0DMV8 | 1-387 | ATPases – Hsp70 | 3JXU |
HSPA1L | Heat shock 70 kDa protein 1-like | P34931 | 1-386 | ATPases – Hsp70 | 3GDQ |
HSPA2 | Heat shock-related 70 kDa protein 2 | P54652 | 6-386 | ATPases – Hsp70 | 3I33 |
HSPA5 | Endoplasmic reticulum chaperone BiP | P11021 | 26-410 | ATPases – Hsp70 | 3IUC |
HSPA6 | Heat shock 70 kDa protein 6 | P17066 | 6-385 | ATPases – Hsp70 | 3FE1 |
HSPA9 | Stress-70 protein, mitochondrial | P38646 | 439-597 | ATPases – Hsp70 | 3N8E |
BRDT | Bromodomain testis-specific protein | Q58F21 | 21-137 | Bromodomain | 2RFJ |
CECR2 | Chromatin remodeling regulator CECR2, bromodomain | Q9BXF3 | 424-538 | Bromodomain | 3NXB |
CREBBP | CREB-binding protein, bromodomain | Q92793 | 1081-1197 | Bromodomain | 3P1D |
EP300 | Histone acetyltransferase p300, bromodomain | Q09472 | 1040-1161 | Bromodomain | 3I3J |
KAT2A | Histone acetyltransferase KAT2A, bromodomain | Q92830 | 729-837 | Bromodomain | 3D7C |
KAT2B | Histone acetyltransferase KAT2B, bromodomain | Q92831 | 715-831 | Bromodomain | 3GG3 |
PBRM1 | Protein polybromo-1, bromodomain | Q86U86 | 43-156 | Bromodomain | 3G0J |
PBRM1 | Protein polybromo-1, bromodomain | Q86U86 | 178-291 | Bromodomain | 3HMF |
PBRM1 | Protein polybromo-1, bromodomain | Q86U86 | 388-494 | Bromodomain | 3IU5 |
PBRM1 | Protein polybromo-1, bromodomain | Q86U86 | 645-766 | Bromodomain | 3IU6 |
PBRM1 | Protein polybromo-1, bromodomain | Q86U86 | 773-917 | Bromodomain | 3K2J |
PHIP | PH-interacting protein, bromodomain 2 | Q8WWQ0 | 1302-1434 | Bromodomain | 3MB3 |
TAF1L | Transcription initiation factor TFIID subunit 1-like, bromodomain | Q8IZX4 | 1523-1654 | Bromodomain | 3HMH |
BACH1 | Transcription regulator protein BACH1, BTB domain | O14867 | 7-128 | BTB-Kelch | 2IHC |
BTBD6 | BTB/POZ domain-containing protein 6 | Q96KE9 | 129-236 | BTB-Kelch | 2VKP |
GAN | Gigaxonin, BTB domain | Q9H2C0 | 6-126 | BTB-Kelch | 2PPI |
KLHL11 | Kelch-like protein 11 | Q9NVR0 | 67-340 | BTB-Kelch | 3I3N |
KLHL12 | Kelch-like protein 12 | Q53G59 | 267-567 | BTB-Kelch | 2VPJ |
KLHL2 | Kelch-like protein 2 | O95198 | 294-591 | BTB-Kelch | 2XN4 |
KLHL7 | Kelch-like protein 7 | Q8IXQ5 | 283-586 | BTB-Kelch | 3II7 |
MYNN | Myoneurin, BTB domain | Q9NPC7 | 4-117 | BTB-Kelch | 2VPK |
ZBTB33 | Transcriptional regulator Kaiso, BTB domain | Q86T24 | 1-116 | BTB-Kelch | 3FKC |
ZBTB48 | Telomere zinc finger-associated protein, BTB domain | P10074 | 4-120 | BTB-Kelch | 3B84 |
RADIL | Ras-associating and dilute domain-containing protein, Ras association domain | Q96JH8 | 51-193 | Cell-type specific expression – endothelial cell | 3EC8 |
GUCY1B1 | Guanylate cyclase 1, soluble, beta-1 | Q02153 | 408-619 | Cyclase-Nucleotide | 2WZ1 |
MACROD1 | ADP-ribose glycohydrolase MACROD1, MACRO domain | Q9BQ69 | 91-325 | Deacetyalases | 2X47 |
RECQL | ATP-dependent DNA helicase Q1 | P46063 | 49-616 | DEAD-DNA-Helicase | 2V1X |
ALDH1L1 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | O75891 | 1-307 | Dehydrogenases & Reductases – Other DRs | 2BW0/2CFI |
DPYSL2ᅠᅠᅠ | Dihydropyrimidinase-related protein 2 | Q16555 | 13-490 | Dehydrogenases & Reductases – Other DRs | 2GSE |
DPYSᅠᅠᅠ | Dihydropyrimidinase | Q14117 | 1-519 | Dehydrogenases & Reductases – Other DRs | 2VR2 |
CBLB | E3 ubiquitin-protein ligase CBL-B | Q13191 | 38-344 | E3-Ligase | 3PFV |
CBLC | E3 ubiquitin-protein ligase CBL-C | Q9ULV8 | 9-323 | E3-Ligase | 3OP0 |
CUL5 | Cullin-5 | Q9D5V5 | 1-386 | E3-Ligase | 2WZK |
ERI3 | ERI1 exoribonuclease 3 | O43414 | 137-337 | Endo/Exo Nucleases | 2XRI |
EXOG | Nuclease EXOG, mitochondrial | Q9Y2C4 | 42-368 | Endo/Exo Nucleases | 4A1N |
ASH1L | Histone-lysine N-methyltransferase ASH1L, bromodomain | Q9NR48 | 2438-2561 | Epigenetic targets: Bromodomains | 3MQM |
BAZ2B | Bromodomain adjacent to zinc finger domain protein 2B | Q9UIF8 | 2054-2168 | Epigenetic targets: Bromodomains | 3G0L |
BPTF | Nucleosome-remodeling factor subunit BPTF, bromodomain | Q12830 | 2914-3037 | Epigenetic targets: Bromodomains | |
BRD1 | Bromodomain-containing protein 1 | O95696 | 556-688 | Epigenetic targets: Bromodomains | 3RCW |
BRD9 | Bromodomain-containing protein 9 | O95696 | 134-239 | Epigenetic targets: Bromodomains | 3HME |
BRWD1 | Bromodomain and WD repeat-containing protein 1, bromodomain 2 | Q9NSI6 | 1310-1430 Bromodomain 2 | Epigenetic targets: Bromodomains | 3Q2E |
MINA | Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA | Q8IUF8 | 26-465 | Epigenetic targets: Demethylases | 2XDV |
RGS1 | Regulator of G-protein signalling 1 | Q08116 | 63-205 | G-protein-Regulator | 2BV1 |
RGS10 | Regulator of G-protein signalling 10 (isoform b) | O43665 | 30-165 | G-protein-Regulator | 2I59 |
RGS14 | Regulator of G-protein signalling 14 | O43566 | 56-207 | G-protein-Regulator | 2JNU |
RGS16 | Regulator of G-protein signalling 16 | O15492 | 53-190 | G-protein-Regulator | 2BT2 |
RGS17 | Regulator of G-protein signalling 17 | Q9UGC6 | 72-206 | G-protein-Regulator | 1ZV4 |
RGS18 | Regulator of G-protein signalling 18 | Q9NS28 | 75-223 | G-protein-Regulator | 2OWI |
RGS2 | Regulator of G-protein signalling 2 | P41220 | 71-203 | G-protein-Regulator | 2AF0 |
RGS3 | Regulator of G-protein signalling 3 (isoform 1), PDZ domain | P49796 | 299-384 | G-protein-Regulator | 2F5Y |
RGS6 | Regulator of G-protein signalling 6 | P49758 | 325-470 | G-protein-Regulator | 2ES0 |
RGS7 | Regulator of G-protein signalling 7 | P49802 | 320-463 | G-protein-Regulator | 2A72 |
RGS8 | Regulator of G-protein signalling 8 | P57771 | 42-173 | G-protein-Regulator | 2IHD |
ARHGAP15 | Rho GTPase-activating protein 15 | Q53QZ3 | 262-473 | GTPase-GAP | 3BYI |
RACGAP1 | Rac GTPase-activating protein 1 | Q9H0H5 | 348-546 | GTPase-GAP | 2OVJ |
AGAP2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, GTPase like domain | Q99490 | 402-577 | GTPase-RAS | 2IWR |
DIRAS1 | GTP-binding protein Di-Ras1 | O95057 | 1-198 | GTPase-RAS | 2GF0 |
DIRAS2 | GTP-binding protein Di-Ras2 | Q96HU8 | 5-176 | GTPase-RAS | 2ERX |
GEM | GTP-binding protein GEM | P55040 | 62-249 | GTPase-RAS | 2G3Y |
REM1 | GTP-binding protein REM 1 | O75628 | 79-251 | GTPase-RAS | 2NZJ |
RERG | Ras-related and estrogen-regulated growth inhibitor | Q96A58 | 1-174 | GTPase-RAS | 2ATV |
RRAD | GTP-binding protein RAD | P55042 | 87-260 | GTPase-RAS | 2GJS |
RRAS | Ras-related protein R-Ras | P10301 | 23-201 | GTPase-RAS | 2FN4 |
RRAS2 | Ras-related protein R-Ras2 | P62070 | 12-181 | GTPase-RAS | 2ERY |
RAC3 | Ras-related C3 botulinum toxin substrate 3 | P60763 | 1-192 | GTPase-RHO | 2C2H |
RHOB | Rho-related GTP-binding protein RhoB | P62745 | 4-184 | GTPase-RHO | 2FV8 |
RHOD | Rho-related GTP-binding protein RhoD | O00212 | 7-197 | GTPase-RHO | 2J1L |
RHOU | Rho-related GTP-binding protein RhoU | Q7L0Q8 | 32-230 | GTPase-RHO | 2Q3H |
RND1 | Rho-related GTP-binding protein Rho6 | Q92730 | 5-200 | GTPase-RHO | 2CLS |
ADA | Adenosine deaminase | P00813 | 5-363 | Hydrolase-Other | 3IAR |
ECH1 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial | Q13011 | 39-49,50-322 | Hydrolase-Other | 2VRE |
ECHDC3 | Enoyl-CoA hydratase domain-containing protein 3, mitochondrial | Q96DC8 | 37-300 | Hydrolase-Other | 2VX2 |
ECHS1 | Enoyl-CoA hydratase, mitochondrial | P30084 | 28-290 | Hydrolase-Other | 2HW5 |
ERAP1 | Endoplasmic reticulum aminopeptidase 1 | Q9NZ08 | 1-505 | Hydrolase-Other | 2XDT |
FH | Fumarate hydratase, mitochondrial | P07954 | 44-510 | Hydrolase-Other | 3E04 |
HDHD2 | Haloacid dehalogenase-like hydrolase domaing-containing 2 | Q9H0R4 | 1-259 | Hydrolase-Other | 3HLT |
HDHD3 | Haloacid dehalogenase-like hydrolase domain-containing 3 | Q9BSH5 | 8-247 | Hydrolase-Other | 3K1Z |
HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial | Q6NVY1 | 32-386 | Hydrolase-Other | 3BPT |
MDP1 | Magnesium-dependent phosphatase 1 | Q86V88 | 1-165 | Hydrolase-Other | 2WM8 |
PTS | 6-pyruvoyltetrahydropterin synthase | Q03393 | 7-145 | Hydrolase-Other | 3I2B |
PUDP | Pseudouridine-5′-phosphatase | Q08623 | 1-228 | Hydrolase-Other | 3L5K |
ECI2 | Enoyl-CoA delta isomerase 2 | O75521 | 137-394 | Isomerase | 2F6Q |
MMUT | Methylmalonyl-CoA mutase, mitochondrial | P22033 | 12-750 | Isomerase | 3BIC |
AKT3 | RAC-gamma serine/threonine-protein kinase | Q9Y243 | 1-118 | Kinase-AGC | 2X18 |
DMPK | Myotonin-protein kinase | Q09013 | 10-420 | Kinase-AGC | 2VD5 |
MAST1 | Microtubule associated serine/threonine kinase 1, PDZ domain | Q9Y2H9 | 965-1057 | Kinase-AGC | 3PS4 |
MAST3 | Microtubule associated serine/threonine kinase 3, PDZdomain | O60307 | 948-1040 | Kinase-AGC | 3KHF |
MAST4 | Microtubule-associated serine/threonine-protein kinase 4 , PDZ domain | O15021 | 1140-1231 | Kinase-AGC | 2W7R |
PRKCG | Protein kinase C gamma type, C2 domain | P05129 | 154-295 | Kinase-AGC | 2UZP |
RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | Q15418 | 404-719 | Kinase-AGC | 2WNT |
CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Q8IU85 | 1-333 | Kinase-CAMK | 2JC6 |
CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | Q96NX5 | 18-316 | Kinase-CAMK | 2JAM |
CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Q9UQM7 | 13-302 | Kinase-CAMK | 2VZ6 |
CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Q13554 | 11-303 | Kinase-CAMK | 3BHH |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Q13557 | 11-309 | Kinase-CAMK | 2VN9 |
CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Q13557 | 334-475 | Kinase-CAMK | 2W2C |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Q13555 | 5-315 | Kinase-CAMK | 2V7O |
CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Q13555 | 425-558 | Kinase-CAMK | 2UX0 |
CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Q16566 | 15-340 | Kinase-CAMK | 2W4O |
MYLK4 | Myosin light chain kinase family, member 4 | Q86YV6 | 40-388 | Kinase-CAMK | 2X4F |
PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | P15735 | 6-293 | Kinase-CAMK | 2Y7J |
PIM2 | Serine/threonine-protein kinase | Q9P1W9 | 1-311 | Kinase-CAMK | 2IWI |
CSNK1G1 | Casein kinase I isoform gamma-1 | P78368 | 45-352 | Kinase-CK1 | 2CMW |
CSNK1G2 | Casein kinase I isoform gamma-2 | Q9HCP0 | 43-353 | Kinase-CK1 | 2C47 |
CSNK1G3 | Casein kinase I isoform gamma-3 | Q9Y6M4 | 35-362 | Kinase-CK1 | 2IZR |
VRK1 | Serine/threonine-protein kinase VRK1, protein kinase domain | Q99986 | 3-364 | Kinase-CK1 | 3OP5 |
VRK2 | Serine/threonine-protein kinase VRK2, protein kinase domain | Q86Y07 | 14-335 | Kinase-CK1 | 2V62 |
VRK3 | Serine/threonine-protein kinase VRK3, protein kinase domain | Q8IV63 | 138-474 | Kinase-CK1 | 2JII |
CLK1 | Dual specificity protein kinase CLK1 | P49759 | 148-484 | Kinase-CMGC | 1Z57 |
CLK2 | Dual specificity protein kinase CLK2 | P49760 | 135-496 | Kinase-CMGC | 3NR9 |
DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Q92630 | 146-552 | Kinase-CMGC | 3K2L |
MAPK11 | Mitogen-activated protein kinase 11 (p38b) | Q15759 | 5-350 | Kinase-CMGC | 3GP0 |
MAPK6 | Mitogen-activated protein kinase 6 | Q16659 | 9-327 | Kinase-CMGC | 2I6L |
PCTK1 | Cyclin-dependent kinase 16 | Q00536 | 163-478 | Kinase-CMGC | 3MTL |
SRPK2 | SFRS protein kinase 2 | P78362 | 50-688 | Kinase-CMGC | 2X7G |
GAK | Cyclin-G-associated kinase | O14976 | 12-347 | Kinase-Other | 3LL6 |
PTK2B | Protein-tyrosine kinase 2-beta | Q14289 | 414-692 | Kinase-Other | 3CC6 |
STK16 | Serine/threonine protein kinase 16 | O75716 | 13-305 | Kinase-Other | 2BUJ |
TTK | Dual specificity protein kinase TTK | P33981 | 519-808 | Kinase-Other | 3CEK |
ITPK1 | Inositol-tetrakisphosphate 1-kinase | Q13572 | 1-327 | Kinase-PIK | 2ODT |
ITPKC | Inositol-trisphosphate 3-kinase C | Q96DU7 | 425-683 | Kinase-PIK | 2A98 |
PIK3C2G | Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma, PX domain | O75747 | 1198-1307 | Kinase-PIK | 2WWE |
PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | Q8NEB9 | 282-879 | Kinase-PIK | 3IHY |
PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | Q8NEB9 | 268-879 | Kinase-PIK | 3LS8 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | O00459 | 108-298 | Kinase-PIK | 2XS6 |
PIP5K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Q8TBX8 | 32-421 | Kinase-PIK | 2GK9 |
MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | P52564 | 47-334 | Kinase-STE | 3FME |
MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 (isoform 2) PB1 domain | Q99759 | 27-124 | Kinase-STE | 2C60 |
MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase kinase 5) | Q99683 | 659-951 | Kinase-STE | 2CLQ |
PAK4 | Serine/threonine-protein kinase PAK 4 | O96013 | 291-591 | Kinase-STE | 2Q0N |
PAK5 | Serine/threonine-protein kinase PAK 5 | Q9P286 | 425-719 | Kinase-STE | 2F57 |
PAK6 | Serine/threonine-protein kinase PAK 6 | Q9NQU5 | 383-681 | Kinase-STE | 2C30 |
SLK | STE20-like serine/threonine-protein kinase | Q9H2G2 | 12-15,16-320 | Kinase-STE | 2UV2 |
STK25 | Serine/threonine-protein kinase 25 | O00506 | 1-293 | Kinase-STE | 2XIK |
STK26 | Serine/threonine-protein kinase 26 | Q9P289 | 1-300 | Kinase-STE | 3GGF |
TNIK | TRAF2 and NCK interacting protein kinase | Q9UKE5 | 1-325 | Kinase-STE | 2X7F |
ABL2 | Tyrosine-protein kinase ABL2 | P42684 | 279-546 | Kinase-TK | 3GVU |
FES | Tyrosine-protein kinase Fes/Fps | P07332 | 448-822 | Kinase-TK | 3BKB |
FLT1 | Vascular endothelial growth factor receptor 1 | P17948 | 801-1158 | Kinase-TK and PARP domain? | 3HNG |
ACVR1 | Activin receptor type-1 | Q04771 | 201-499 | Kinase-TKL | 3MTF |
ACVR2A | Activin receptor type-2A | P27037 | 191-488 | Kinase-TKL | 3SOC |
ACVRL1 | Serine/threonine-protein kinase receptor R3 | P37023 | 195-497 | Kinase-TKL | 3MY0 |
LIMK1 | LIM domain kinase 1 (isoform 1), kinase domain | P53667 | 330-637 | Kinase-TKL | 3S95 |
MAP3K10 | Mitogen-activated protein kinase kinase kinase 10, SH3 domains | Q02779 | 13-78 | Kinase-TKL | 2RF0 |
ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Q01974 | 463-751 | Kinase-Tyr | 3ZZW |
AK1 | Adenylate kinase isoenzyme 1 | P00568 | 1-193 | Kinases | 2C95 |
AK2 | Adenylate kinase isoenzyme 2, mitochondrial | P54819 | 1-239 | Kinases | 2C9Y |
AK4 | Adenylate kinase isoenzyme 4, mitochondrial | P27144 | 1-223 | Kinases | 2BBW |
AK5 | Adenylate kinase isoenzyme 5 | Q9Y6K8 | 366-562 | Kinases | 2BWJ |
BMPR2 | Bone morphogenetic protein receptor type-2 | Q13873 | 189-517 | Kinases | 3G2F |
HASPIN | Serine/threonine-protein kinase haspin | Q8TF76 | 465-798 | Kinases | |
MPSK1 | Serine/threonine-protein kinase 16 | O75716 | 13-305 | Kinases | |
MST4 | Serine/threonine-protein kinase | Q9P289 | 1-300 | Kinases | |
NEK2 | Serine/threonine-protein kinase | P51955 | 1-271 | Kinases | 2JAV |
ACACA | Acetyl-CoA carboxylase 1 | Q13085 | 78-617 | Ligase | 2YL2 |
PCCA | Propionyl-Coenzyme A carboxylase, alpha polypeptide precursor | P05165 | 658-728 | Ligase | 2JKU |
ACSM2A | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | Q08AH3 | 32-577 | Ligase AMP-Binding | 3C5E |
DLG2 | Discs, large homolog 2, second PDZ domain | Q15700 | 418-513 | Linker-PDZ | 2HE2 |
DLG2 | Discs, large homolog 2, first PDZ domain | Q15700 | 190-283 | Linker-PDZ | 2BYG |
DLG3 | Discs, large homolog 3 first PDZ domain | Q92796 | 126-222 | Linker-PDZ | 2I1N |
DLG3 | Discs, large homolog 3 second PDZ domain | Q92796 | 223-314 | Linker-PDZ | 2FE5 |
DVL2 | Segment polarity protein dishevelled homolog DVL-2, PDZ domain | O14641 | 261-355 | Linker-PDZ | 2REY |
GIPC2 | PDZ domain-containing protein GIPC2 | Q8TF65 | 112-200 | Linker-PDZ | 3GGE |
GRIP1 | Glutamate receptor interacting protein 1, 2nd PDZ domain | Q9Y3R0 | 148-239 | Linker-PDZ | 2JIL |
LNX1 | E3 ubiquitin-protein ligase LNX, PDZ domain | Q8TBB1 | 504-594 | Linker-PDZ | 3B76 |
LNX2 | Ligand of Numb protein X 2, PDZ domain | Q8N448 | 336-425 | Linker-PDZ | 2VWR |
MAGI1 | Membrane associated guanylate kinase WW and PDZ containing protein 1, 4th PDZ domain | Q96QZ7 | 839-922 | Linker-PDZ | 2Q9V |
MAGI1 | Membrane associated guanylate kinase WW and PDZ containing protein 1, 6th PDZ domain containing C1190S mutant | Q96QZ7 | 1149-1233 | Linker-PDZ | 2R4H |
MAGI1 | Membrane associated guanylate kinase WW and PDZ containing protein 1, 3th PDZ domain continaing double mutant, C677S and C709S | Q96QZ7 | 640-721 | Linker-PDZ | 3BPU |
MPDZ | Multiple PDZ domain protein, 1st PDZ domain | O75970 | 117-227 | Linker-PDZ | 2O2T |
MPDZ | Multiple PDZ domain protein, 3rd PDZ domain | O75970 | 373-463 | Linker-PDZ | 2IWN |
MPDZ | Multiple PDZ domain protein, 7th PDZ domain | O75970 | 1148-1243 | Linker-PDZ | 2FCF |
MPDZ | Multiple PDZ domain protein, 12th PDZ domain | O75970 | 1858-1951 | Linker-PDZ | 2IWO |
MPDZ | Multiple PDZ domain protein, 13th PDZ domain | O75970 | 1983-2070 | Linker-PDZ | 2FNE |
MPDZ | Multiple PDZ domain protein, 10th PDZ domain | O75970 | 1625-1716 | Linker-PDZ | 2OPG |
MPDZ | Multiple PDZ domain protein, 11th PDZ domain | O75970 | 1722-1806 | Linker-PDZ | 2QG1 |
NHERF1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1, PDZ domain | O14745 | 150-235 | Linker-PDZ | 2OZF |
NHERF2 | Na(+)/H(+) exchange regulatory cofactor NHE-RF2, PDZ domain | Q15599 | 147-230 | Linker-PDZ | 2HE4 |
NHERF2 | Na(+)/H(+) exchange regulatory cofactor NHE-RF2, PDZ domain | Q15599 | 9-91 | Linker-PDZ | 2OCS |
NHERF4 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4, PDZ domain | Q86UT5 | 326-419 | Linker-PDZ | 2V90 |
PDLIM1 | PDZ and LIM domain protein 1, PDZ domain | O00151 | 1-87 | Linker-PDZ | 2PKT |
PDLIM2 | PDZ and LIM domain protein 2, PDZ domain | Q96JY6 | 1-82 | Linker-PDZ | 2PA1 |
PDLIM4 | PDZ and LIM domain protein 4, PDZ domain | P50479 | 1-87 | Linker-PDZ | 2V1W |
PDLIM5 | PDZ and LIM domain protein 5, PDZ domain | Q96HC4 | 1-85 | Linker-PDZ | 2UZC |
PDLIM7 | PDZ and LIM domain protein 7, PDZ domain | Q9NR12 | 1-84 | Linker-PDZ | 2Q3G |
PDZK1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3, PDZ domain | Q5T2W1 | 375-461 | Linker-PDZ | 2VSP |
PICK1 | RKCA-binding protein, PDZ domain | Q9NRD5 | 18-105 | Linker-PDZ | 2GZV |
RHPN2 | Rhophilin-2, PDZ domain | Q8IUC4 | 514-598 | Linker-PDZ | 2VSV |
SCRIB | Protein scribble homolog, PDZ domain | Q14160 | 725-815 | Linker-PDZ | 2W4F |
SNTB2 | Beta-2-syntrophin, PDZ domain | Q13425 | 112-200 | Linker-PDZ | 2VRF |
SYNJ2BP | Synaptojanin 2 binding protein, PDZ domain | P57105 | 5-101 | Linker-PDZ | 2JIK |
TAMALIN | GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein, PDZ domain | Q7Z6J2 | 97-192 | Linker-PDZ | 2PNT |
TAX1BP3 | Tax1-binding protein 3, PDZ domain | O14907 | 11-124 | Linker-PDZ | 2VZ5 |
ACOT11 | Acyl-coenzyme A thioesterase 11, START domain | Q8WXI4 | 339-543 | Lipid signalling-Other | 3FO5 |
ACOT12 | Acyl-coenzyme A thioesterase | Q8WYK0 | 7-316 | Lipid signalling-Other | 3B7K |
ACOT4 | Peroxisomal succinyl-coenzyme A thioesterase | Q8N9L9 | 1-421 | Lipid signalling-Other | 3K2I |
ACOT7 | Cytosolic acyl coenzyme A thioester hydrolase | O00154 | 209-378 | Lipid signalling-Other | 2QQ2 |
bphA4 | Biphenyl dioxygenase ferredoxin reductase subunit | E7FJB9 | 1-408 | Lipid signalling-Other | 2H4U |
EPB41L3 | Band 4.1-like protein 3, FERM domain | Q9Y2J2 | 108-390 | Lipid signalling-Other | 2HE7/3BIN |
FABP1 | Fatty acid-binding protein, liver | P07148 | 1-127 | Lipid signalling-Other | 2F73 |
STARD13 | StAR-related lipid transfer protein 13, START domain | Q9Y3M8 | 903-1113 | Lipid signalling-Other | 2PSO |
STARD5 | StAR-related lipid transfer protein 5, START domain | QN9SY2 | 6-213 | Lipid signalling-Other | 2R55 |
LCN15 | Lipocalin-15 | Q6UWW0 | 19-177 | Lipocalin | 2XST |
PMP2 | Myelin P2 protein | P02689 | 3-132 | Lipocalin | 3NR3 |
CA13 | Carbonic anhydrase 13 | Q8N1Q1 | 1-261 | Lyase-Carbonic-Anhydrase | 3DA2 |
CA6 | Carbonic anhydrase 6 | P23280 | 20-290 | Lyase-Carbonic-Anhydrase | 3FE4 |
CA7 | Carbonic anhydrase 7 | P43166 | 5-262 | Lyase-Carbonic-Anhydrase | 3MDZ |
CA8 | Carbonic anhydrase-related protein | P35219 | 1-290 | Lyase-Carbonic-Anhydrase | 2W2J |
HTD2 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial | P86397 | 23-168 | Lyase-Other | 3IR3 |
MLYCD | Malonyl-CoA decarboxylase | O95822 | 40-490 | Lyase-Other | 2YGW |
MAGEA4 | Melanoma antigen family A, 4 | P43358 | 99-317 | MAGE | 2WA0 |
RAMP2 | Receptor activity-modifying protein 2 | O60895 | 48-139 | Membrane-GPCR | 2XVT |
GHRHR | Growth hormone-releasing hormone receptor | Q02643 | 34-123 | Membrane-GPCR-ECD | 2XDG |
VIPR2 | Vasoactive intestinal polypeptide receptor 2, hormone receptor domain | P41587 | 26-118 | Membrane-GPCR-ECD | 2X57 |
ELAC1 | Zinc phosphodiesterase ELAC protein 1 | Q9H777 | 3-363 | Metallo-Beta-Lactamase? Zinc phosphodiesterase | 3ZWF |
HSP90B1 | Heat shock protein HSP 90-beta | P08238 | 284-543 | Miscellaneous | 3PRY |
MMACHC | Cyanocobalamin reductase or alkylcobalamin dealkylase | Q9Y4U1 | 1-282 | Miscellaneous | 3SOM |
TATDN1 | Deoxyribonuclease TATDN1 | Q6P1N9 | 5-295 | Miscellaneous | 2XIO |
TATDN3 | Putative deoxyribonuclease TATDN3 | Q17R31 | 5-274 | Miscellaneous | 2Y1H |
TP73 | Tumor protein p73 | O15350 | 112-311 | Miscellaneous | 2XWC |
NUMBL | Numb-like protein | Q9Y6R0 | 60-204 | Neuronal stem cell development | 3F0W |
TH | Tyrosine 3-monooxygenase | P07101 | 193-528 | Neurotransmitter-Synthesis | 2XSN |
ADAT2 | tRNA-specific adenosine deaminase 2 | Q7Z6V5 | 20-185 | Nucleotide metabolism-Deaminases | 3DH1 |
GDAᅠᅠᅠ | Guanine deaminase | Q9Y2T3 | 1-454 | Nucleotide metabolism-Deaminases | 2UZ9 |
ITPKB | Inosine triphosphate pyrophosphatase | Q9BY32 | 1-194 | Nucleotide metabolism-Nucleotide phosphatases | 2CAR/2J4E |
RRM1 | Ribonucleoside-diphosphate reductase large subunit | P23921 | 75-742 | Nucleotide metabolism-Nucleotide reductases | 2WGH |
RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | P31350 | 60-389 | Nucleotide metabolism-Nucleotide reductases | 2UW2 |
RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | Q7LG56 | 17-322 | Nucleotide metabolism-Nucleotide reductases | 2VUX |
NUDT1 | Oxidized purine nucleoside triphosphate hydrolase | P36639 | 1-156 | Nucleotide metabolism-NUDIX | 3Q93 |
NUDT10 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha | Q8NFP7 | 17-144 | Nucleotide metabolism-NUDIX | 3MCF |
NUDT14 | Uridine diphosphate glucose pyrophosphatase | O95848 | 28-222 | Nucleotide metabolism-NUDIX | 3Q91 |
NUDT16 | U8 snoRNA-decapping enzyme | Q96DE0 | 1-195 | Nucleotide metabolism-NUDIX | 3COU/’2XSQ |
NUDT16L1 | Protein syndesmos | Q9BRJ7 | 6-211 | Nucleotide metabolism-NUDIX | 3KVH |
NUDT18 | 8-oxo-dGDP phosphatase NUDT18 | Q6ZVK8 | 26-179 | Nucleotide metabolism-NUDIX | 3GG6 |
NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 | O43809 | 19-227 | Nucleotide metabolism-NUDIX | 2CL3 |
NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 | O43809 | 20-227 | Nucleotide metabolism-NUDIX | 2J8Q |
NUDT6 | Nucleoside diphosphate-linked moiety X motif 6 | P53370 | 141-316 | Nucleotide metabolism-NUDIX | 3FXT |
ADSLᅠᅠᅠ | Adenylosuccinate lyase | P30566 | 1-481 | Nucleotide metabolism-Others | 2J91/2VD6 |
ADSS2 | Adenylosuccinate synthetase isozyme 2 | P30520 | 21-456 | Nucleotide metabolism-Others | 2V40 |
CTPS1 | CTP synthase 1, synthase domain | P17812 | 1-273 | Nucleotide metabolism-Others | 2C5M/2VO1 |
CTPS2 | CTP synthase 2, glutaminase domain | Q9NRF8 | 292-562 | Nucleotide metabolism-Others | 2V4U/2VKT |
CTPS2 | CTP synthase 2, synthase domain | Q9NRF8 | 1-275 | Nucleotide metabolism-Others | 3IHL |
DCTDᅠᅠᅠ | Deoxycytidylate deaminase | P32321 | 4-174 | Nucleotide metabolism-Others | 2W4L |
GART | Trifunctional purine biosynthetic protein adenosine-3 | P22102 | 1-430 | Nucleotide metabolism-Others | 2QK4 |
GART | Trifunctional purine biosynthetic protein adenosine-3 | P22102 | 467-794 | Nucleotide metabolism-Others | 2V9Y |
GMPS | GMP synthetase [glutamine hydrolyzing], glutaminase domain | P49915 | 11-219 | Nucleotide metabolism-Others | 2VPI |
GMPS | GMP synthetase [glutamine hydrolyzing] | P49915 | 20-693 | Nucleotide metabolism-Others | 2VXO |
PRPSAP1ᅠᅠᅠ | Phosphoribosyl pyrophosphate synthase-associated protein 1 | Q14558 | 1-351 | Nucleotide metabolism-Others | 2C4K |
PRPSAP2 | Phosphoribosyl pyrophosphate synthase-associated protein 2 | O60256 | 12-369 | Nucleotide metabolism-Others | 2JI4 |
PRTFDC1 | Phosphoribosyltransferase domain-containing protein 1 | Q9NRG1 | 1-225 | Nucleotide metabolism-Others | 2JBH |
UCK1 | Uridine-cytidine kinase 1 | Q9HA47 | 21-243 | Nucleotide metabolism-Others | 2JEO/2UVQ |
UMPS | Uridine 5′-monophosphate synthase | P11172 | 224-479 | Nucleotide metabolism-Others | 2JGY/2V30 |
UMPS | Uridine 5′-monophosphate synthase | P11172 | 7-203 | Nucleotide metabolism-Others | 2WNS |
UPP2 | Uridine phosphorylase 2 | O95045 | 23-317 | Nucleotide metabolism-Others | 2XRF |
CCNT2 | Cyclin-T2 | O60583 | 7-263 | Other-Cyclin | 2IVX |
ACBD4 | Acyl-CoA-binding domain-containing protein 4 | Q8NC06 | 7-110 | Other-NonDR | 2WH5 |
ACBD5 | Acyl-CoA-binding domain-containing protein 5 | Q5T8D3 | 41-136 | Other-NonDR | 3FLV |
ACBD7 | Acyl-CoA-binding domain-containing protein 7 | Q8N6N7 | 1-88 | Other-NonDR | 3EPY |
CRYBA4 | Beta-crystallin A4 | P53673 | 8-196 | Other-NonDR | 3LWK |
CRYBB3 | Beta-crystallin B3 | P26998 | 21-199 | Other-NonDR | 3QK3 |
FDX1 | Adrenodoxin, mitochondrial | P10109 | 61-184 | Other-NonDR | 3P1M |
GMFG | Glia maturation factor gamma | O60234 | 7-140 | Other-NonDR | 3L50 |
LHPP | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase | Q9H008 | 1-270 | Other-NonDR | 2X4D |
MMAA | Methylmalonic aciduria type A protein, mitocondrial | Q8IVH4 | 70-418 | Other-NonDR | 2WWW |
TTC5 | Tetratricopeptide repeat protein 5 | Q8N0Z6 | 261-424 | Other-Signal | 2XVS |
TWF2 | Twinfilin-2 | Q6IBS0 | 6-137 | Other-Signal | 2VAC |
TWF2 | Twinfilin-2 | Q6IBS0 | 179-313 | Other-Signal | 2W0I |
YWHAB | 14-3-3 protein beta/alpha | P31946 | 1-240 | Other-Signal | 2BQ0 |
YWHAE | 14-3-3 protein epsilon | P62258 | 1-233 | Other-Signal | 2BR9 |
YWHAG | 14-3-3 protein gamma | P61981 | 2-247 | Other-Signal | 2B05 |
YWHAH | 14-3-3 protein eta | Q04917 | 1-246 | Other-Signal | 2C74 |
YWHAQ | 14-3-3 protein theta | P27348 | 1-234 | Other-Signal | 2BTP |
ASPH | Aspartyl/asparaginyl beta-hydroxylase | Q12797 | 562-758 | Oxidoreductase-2OG | 3RCQ |
BBOX1 | Gamma-butyrobetaine dioxygenase | O75936 | 1-387 | Oxidoreductase-2OG | 3MS5 |
JMJD6 | Bifunctional arginine demethylase and lysyl-hydroxylase | Q6NYC1 | 2-335 | Oxidoreductase-2OG | 3K2O |
KDM4A | Lysine-specific demethylase 4A | O75164 | 1-359 | Oxidoreductase-2OG | 2OQ7 |
KDM4C | Lysine-specific demethylase 4C | Q9H3R0 | 875-995 | Oxidoreductase-2OG | 2XDP |
KDM4E | Lysine-specific demethylase 4E | B2RXH2 | 1-336 | Oxidoreductase-2OG | 2W2I |
KDM5C | Lysine-specific demethylase 5C | P41229 | 73-188 | Oxidoreductase-2OG | 2JRZ |
KDM6B | Lysine-specific demethylase 6B | O15054 | 1176-1505 | Oxidoreductase-2OG | 2XXZ |
PHF8 | Histone lysine demethylase PHF8 | Q9UPP1 | 115-483 | Oxidoreductase-2OG | 2WWU |
PHYHD1 | hytanoyl-CoA dioxygenase domain-containing protein 1 | Q5SRE7 | 1-291 | Oxidoreductase-2OG | 2OPW |
ACAD11 | Acyl-CoA dehydrogenase family member 11 | Q709F0 | 353-780 | Oxidoreductase-Acyl-CoA | 2WBI |
ACADS | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | P16219 | 30-412 | Oxidoreductase-Acyl-CoA | 2VIG |
ACADSB | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial | P45954 | 52-432 | Oxidoreductase-Acyl-CoA | 2JIF |
ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | P49748 | 69-655 | Oxidoreductase-Acyl-CoA | 2UXW |
AKR1C4 | Aldo-keto reductase family 1 member C4 | P17516 | 1-323 | Oxidoreductase-AKR | 2FVL |
AKR7A2 | Aflatoxin B1 aldehyde reductase member 2 | O43488 | 1-359 | Oxidoreductase-AKR | 2BP1 |
AKR7A3 | Aflatoxin B1 aldehyde reductase member 3 | O95154 | 6-331 | Oxidoreductase-AKR | 2CLP |
ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase | P54886 | 362-795 | Oxidoreductase-ALDH | 2H5G |
ALDH7A1 | Alpha-aminoadipic semialdehyde dehydrogenase | P49419 | 29-527 | Oxidoreductase-ALDH | 2J6L |
GPX1 | Glutathione peroxidase 1 | P07203 | 14-198 | Oxidoreductase-GPX | 2F8A |
GPX2 | Glutathione peroxidase 2 | P18283 | 4-188 | Oxidoreductase-GPX | 2HE3 |
GPX3 | Glutathione peroxidase 3 | P22352 | 25-223 | Oxidoreductase-GPX | 2R37 |
GPX4 | Glutathione peroxidase 4 | P36969 | 36-197 | Oxidoreductase-GPX | 2GS3 |
GPX5 | Epididymal secretory glutathione peroxidase | O75715 | 28-220 | Oxidoreductase-GPX | 2I3Y |
GPX7 | Glutathione peroxidase 7 | Q96SL4 | 20-177 | Oxidoreductase-GPX | 2P31 |
GPX8 | Probable glutathione peroxidase 8 | Q8TED1 | 44-209 | Oxidoreductase-GPX | 3CYN |
ADH4 | All-trans-retinol dehydrogenase [NAD(+)] ADH4 | P08319 | 1-380 | Oxidoreductase-MDR | 3COS |
FASN | Fatty acid synthase | P49327 | 422-831 | Oxidoreductase-MDR | 2JFK |
MECR | Enoyl-[acyl-carrier-protein] reductase, mitochondrial | Q9BV79 | 40-373 | Oxidoreductase-MDR | 1ZSY |
PTGR1 | Prostaglandin reductase 1 | Q14914 | 4-329 | Oxidoreductase-MDR | 1ZSV |
PTGR2 | Prostaglandin reductase 2 | Q8N8N7 | 1-350 | Oxidoreductase-MDR | 2VNA |
PTGR3 | Prostaglandin reductase 3 | Q8N4Q0 | 33-371 | Oxidoreductase-MDR | 2C0C |
PTGR3 | Prostaglandin reductase 3 | Q8N4Q0 | 31-370 | Oxidoreductase-MDR | 2WEK |
RTN4IP1 | Reticulon-4-interacting protein 1, mitochondrial | Q8WWV3 | 45-396 | Oxidoreductase-MDR | 2VN8 |
TP53I3 | Quinone oxidoreductase PIG3 | Q53FA7 | 1-332 | Oxidoreductase-MDR | 2J8Z |
BLVRA | Biliverdin reductase A | P53004 | 7-296 | Oxidoreductase-Other | 2H63 |
CRYL1 | Lambda-crystallin homolog | Q9Y2S2 | 6-316 | Oxidoreductase-Other | 3F3S |
CTBP2 | C-terminal binding protein 2 | P56545 | 31-364 | Oxidoreductase-Other | 2OME |
GAPDHS | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | O14556 | 69-407 | Oxidoreductase-Other | 3H9E |
GLOD5 | Glyoxalase domain-containing protein 5 | A6NK44 | 34-157 | Oxidoreductase-Other | 3ZW5 |
GLRX2 | Glutaredoxin-2, mitochondrial | Q9NS18 | 41-164 | Oxidoreductase-Other | 2HT9 |
GLRX2 | Glutaredoxin-2, mitochondrial | Q9NS18 | 56-164 | Oxidoreductase-Other | 2FLS |
GLRX3 | Glutaredoxin-3 | O76003 | 1-134 | Oxidoreductase-Other | 2WZ9 |
GLRX3 | Glutaredoxin-3 | O76003 | 232-334 | Oxidoreductase-Other | 2YAN |
GLYR1 | Cytokine-like nuclear factor N-PAC | Q49A26 | 261-553 | Oxidoreductase-Other | 2UYY |
GMPR | GMP reducatse 1 | P36959 | 1-345 | Oxidoreductase-Other | 2BLE |
GPD1L | Glycerol-3-phosphate dehydrogenase 1-like protein | Q8N335 | 1-349 | Oxidoreductase-Other | 2PLA |
HAO1 | 2-Hydroxyacid oxidase 1 | Q9UJM8 | 1-370 | Oxidoreductase-Other | 2NZL |
HIBADH | 3-Hydroxyisobutyrate dehydrogenase, mitochondrial | P31937 | 41-335 | Oxidoreductase-Other | 2GF2 |
HPD | 4-hydroxyphenylpyruvate dioxygenase | P32754 | 8-393 | Oxidoreductase-Other | 3ISQ |
MCEE | Methylmalonyl CoA epimerase | Q96PE7 | 45-176 | Oxidoreductase-Other | 3RMU |
MDH2 | Malate dehydrogenase 2, NAD (mitochondrial) | P40926 | 19-338 | Oxidoreductase-Other | 2DFD |
ME1 | NADP-dependent malic enzyme | P48163 | 13-564 | Oxidoreductase-Other | 2AW5 |
MSRB1 | Methionine-R-sulfoxide reductase B1 | Q9NZV6 | 10-112 | Oxidoreductase-Other | 3MAO |
PGD | 6-phosphogluconate dehydrogenase, decarboxylating | P52209 | 1-483 | Oxidoreductase-Other | 2JKV |
PHGDH | D-3-phosphoglycerate dehydrogenase | O43175 | 4-314 | Oxidoreductase-Other | 2G76 |
PRDX4 | Peroxiredoxin 4 | Q13162 | 84-271 | Oxidoreductase-Other | 2PN8 |
PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial | P32322 | 1-300 | Oxidoreductase-Other | 2IZZ |
TXNRD1 | Thioredoxin reductase 1, cytoplasmic | Q16881 | 150-649 | Oxidoreductase-Other | 2CFY |
TXNRD3 | Thioredoxin reductase 3 | Q86VQ6 | 51-156 | Oxidoreductase-Other | 3H8Q |
UGDH | UDP-glucose 6-dehydrogenase | O60701 | 1-466 | Oxidoreductase-Other | 2Q3E |
BDH2 | Dehydrogenase/reductase SDR family member 6 | Q9BUT1 | 1-245 | Oxidoreductase-SDR | 2AG5 |
CBR3 | Carbonyl reductase [NADPH] 3 | O75828 | 6-277 | Oxidoreductase-SDR | 2HRB |
DHRS1 | Dehydrogenase/reductase SDR family member 1 | Q96LJ7 | 3-262 | Oxidoreductase-SDR | 2QQ5 |
DHRS11 | Dehydrogenase/reductase SDR family member 11 | Q6UWP2 | 1-256 | Oxidoreductase-SDR | 1XG5 |
DHRS4 | Dehydrogenase/reductase SDR family member 4 | Q9BTZ2 | 19-278 | Oxidoreductase-SDR | 3O4R |
GMDS | GDP-mannose 4,6-dehydratase | O60547 | 23-372 | Oxidoreductase-SDR | 1T2A |
HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | P15428 | 3-256 | Oxidoreductase-SDR | 2GDZ |
HSD11B1 | 11-Beta-hydroxysteroid dehydrogenase 1 | P28845 | 20-284 | Oxidoreductase-SDR | 2BEL |
HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Q99714 | 1-261 | Oxidoreductase-SDR | 2O23 |
HSD17B11 | Estradiol 17-beta-dehydrogenase 11 | Q8NBQ5 | 15-275 | Oxidoreductase-SDR | 1YB1 |
HSD17B14 | 17-Beta-hydroxysteroid dehydrogenase 14 | Q9BPX1 | 1-270 | Oxidoreductase-SDR | 1YDE |
HSD17B4 | Peroxisomal multifunctional enzyme type 2 | P51659 | 1-304 | Oxidoreductase-SDR | 1ZBQ |
HSD17B8 | (3R)-3-hydroxyacyl-CoA dehydrogenase | Q92506 | 6-261 | Oxidoreductase-SDR | 2PD6 |
MAT2B | MAT2B: methionine adenosyltransferase II, beta [RefSeq, isoform 2] (aka TGR, MAT-II, MGC12237, MATIIbeta, Nbla02999) | Q9NZL9 | 28-334 | Oxidoreductase-SDR | 2YDX |
NMRAL1 | NmrA-like family domain containing protein 1 | Q9HBL8 | 1-298 | Oxidoreductase-SDR | 2WMD |
PECR | Peroxisomal trans-2-enoyl-CoA reductase | Q9BY49 | 1-303 | Oxidoreductase-SDR | 1YXM |
SPR | Sepiapterin reductase | P35270 | 5-261 | Oxidoreductase-SDR | 1Z6Z |
UXS1 | UDP-glucuronic acid decarboxylase 1 | Q8NBZ7 | 85-402 | Oxidoreductase-SDR | 2B69 |
PARP10 | Protein mono-ADP-ribosyltransferase PARP10 | Q53GL7 | 809-1017 | PARP | 3HKV |
PARP12 | Protein mono-ADP-ribosyltransferase PARP12 | Q9H0J9 | 489-684 | PARP | 2PQF |
PARP14 | Protein mono-ADP-ribosyltransferase PARP14 | Q460N5 | 1611-1801 | PARP | 3GOY |
PARP15 | Protein mono-ADP-ribosyltransferase PARP15 | Q460N3 | 459-656 | PARP | 3BLJ/3GEY |
PARP2 | Poly [ADP-ribose] polymerase 2 | Q9UGN5 | 235-579 | PARP | 3KCZ/3KJD |
PARP3 | Protein mono-ADP-ribosyltransferase PARP3 | Q9Y6F1 | 178-532 | PARP | 2PA9/3C49/3C4H/3CE0/3FHB |
TNKS1 | Poly [ADP-ribose] polymerase tankyrase-1 | O95271 | 1091-1325 | PARP | 2RF5 |
TNKS2 | Poly [ADP-ribose] polymerase tankyrase-2 | Q9H2K2 | 946-1162 | PARP | 3KR7/3P0Q/3P0P/3KR8/3MHJ/3P0N |
TNKS2 | Poly [ADP-ribose] polymerase tankyrase-2 | Q9H2K2 | 955-1162 | PARP | 3MHK |
ZC3HAV1 | Zinc finger CCCH-type antiviral protein 1 | Q7Z2W4 | 724-896 | PARP | 2X5Y |
PARP14 | Protein mono-ADP-ribosyltransferase | Q460N5 | 999-1196 | PARP domain | 3Q71 |
PARP14 | Protein mono-ADP-ribosyltransferase | Q460N5 | 789-979 | PARP domain | 3Q6Z |
pcp | Pyrrolidone-carboxylate peptidase | Q5HCK7 | 1-212 | Pathogen | 3G1U |
Processed | CTP synthase | Q4GZ95 | 319-589 | Pathogen | 2W7T |
TRYB2 | Adenosylhomocysteinase | Q383X0 | 4-437 | Pathogen | 3H9U |
ANLN | Anillin | Q9NQW6 | 980-1113 | PH-Domain | 2Y7B |
CDC25C | M-phase inducer phosphatase 3 | P30307 | 270-462 | Phosphatase-Dual-Spec | 3OP3 |
DUSP13 | Dual specificity protein phosphatase 13B | Q9UII6 | 1-198 | Phosphatase-Dual-Spec | 2PQ5 |
DUSP16 | Dual specificity protein phosphatase 16 | Q9BY84 | 5-150 | Phosphatase-Dual-Spec | 2VSW |
PGAM5 | Serine/threonine-protein phosphatase, mitochondrial | Q96HS1 | 90-289 | Phosphatase-Dual-Spec | 3MXO |
RNGTT | mRNA-capping enzyme | O60942 | 1-219 | Phosphatase-Other | 2C46 |
PTPRB | Receptor-type tyrosine-protein phosphatase beta | P23467 | 1686-1971 | Phosphatase-Tyr-Receptor | 2AHS |
PTPRE | Receptor-type tyrosine-protein phosphatase epsilon | P23469 | 107-697) | Phosphatase-Tyr-Receptor | 2JJD |
PTPRG | Receptor-type tyrosine-protein phosphatase epsilon | P23470 | 827-1445 | Phosphatase-Tyr-Receptor | 2NLK |
PTPRJ | Receptor-type tyrosine-protein phosphatase eta | Q12913 | 1019-1311 | Phosphatase-Tyr-Receptor | 2H4V |
PTPRJ | Receptor-type tyrosine-protein phosphatase eta | Q12913 | 1016-1311 | Phosphatase-Tyr-Receptor | 2CFV |
PTPRK | Receptor-type tyrosine-protein phosphatase eta | Q15262 | 865-1154 | Phosphatase-Tyr-Receptor | 2NZ6 |
PTPRK | Receptor-type tyrosine-protein phosphatase kappa | Q15262 | 853-1154 | Phosphatase-Tyr-Receptor | 2C7S |
PTPRN2 | Receptor-type tyrosine-protein phosphatase N2 | Q92932 | 715-1010 | Phosphatase-Tyr-Receptor | 2QEP |
PTPRO | Receptor-type tyrosine-protein phosphatase O | Q16827 | 916-1208 | Phosphatase-Tyr-Receptor | 2GJT |
PTPRR | Receptor-type tyrosine-protein phosphatase R | Q15256 | 375-655 | Phosphatase-Tyr-Receptor | 2A8B |
PTPRT | Receptor-type tyrosine-protein phosphatase T | O14522 | 868-1151 | Phosphatase-Tyr-Receptor | 2OOQ |
PTPN11 | Tyrosine-protein phosphatase, non-receptor type 11 | Q06124 | 237-529 | Phosphatase-Tyr-Soluble | 3B7O |
PTPN14 | Tyrosine-protein phosphatase non-receptortype 14 | Q15678 | 886-1187 | Phosphatase-Tyr-Soluble | 2BZL |
PTPN18 | Tyrosine-protein phosphatase non-receptor type 18 | Q99952 | 6-299 | Phosphatase-Tyr-Soluble | 2OC3 |
PTPN22 | Tyrosine-protein phosphatase non-receptor type 22 | Q9Y2R2 | 1-302 | Phosphatase-Tyr-Soluble | 2P6X |
PTPN3 | Tyrosine-protein phosphatase non-receptor type 3 | P26045 | 628-913 | Phosphatase-Tyr-Soluble | 2B49 |
PTPN4 | Tyrosine-protein phosphatase non-receptor type 4 | P29074 | 611-926 | Phosphatase-Tyr-Soluble | 2I75 |
PTPN4 | Tyrosine-protein phosphatase non-receptor type 4, PDZ domain | P29074 | 513-610 | Phosphatase-Tyr-Soluble | 2VPH |
PTPN5 | Tyrosine-protein phosphatase non-receptor type 5 | P54829 | 277-563 | Phosphatase-Tyr-Soluble | 2CJZ |
PTPN5 | Tyrosine-protein phosphatase non-receptor type 5 | P54829 | 282-563 | Phosphatase-Tyr-Soluble | 2BV5 |
PTPN7 | Tyrosine-protein phosphatase non-receptor type 7 | P35236 | 65-358 | Phosphatase-Tyr-Soluble | 2A3K |
PTPN9 | Tyrosine-protein phosphatase non-receptor type 9 | P43378 | 277-582 | Phosphatase-Tyr-Soluble | 2PA5 |
MTMR6 | Myotubularin-related protein 6 | Q9Y217 | 1-505 | Phosphatases | |
NANP | N-acylneuraminate-9-phosphatase | Q8TBE9 | 1-248 | Phosphatases | 2W4M |
MTMR6 | Myotubularin-related protein 6 | Q9Y217 | 1-507 | Phosphatases – Other | 2YF0 |
PHPT1 | 14 kDa phosphohistidine phosphatase | Q9NRX4 | 5-125 | Phosphatases – Other | 2HW4 |
PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | Q13362 | 11-380 | Phosphatases – Other | 2JAK |
PTPA | Serine/threonine-protein phosphatase 2A activator | Q15257 | 22-358 | Phosphatases – Other | 2G62 |
THTPA | Thiamine-triphosphatase | Q9BU02 | 1-215 | Phosphatases – Other | 3BHD |
NISCH | Nischarin, PX-domain | Q9Y2I1 | 18-124 | Phosphoinositide dependent signalling – Lipid binding domains | 3P0C |
SNX7 | Sorting nexin-7, Pxdomain | Q9UNH6 | 25-154 | Phosphoinositide dependent signalling – Lipid binding domains | 3IQ2 |
TULP1 | Tubby-related protein 1, Tub family domain | O00294 | 290-542 | Phosphoinositide dependent signalling – Lipid binding domains | 2FIM/3C5N |
NUDT3 | Diphosphoinositol polyphosphate phosphohydrolase 1 | O95989 | 1-172 | Phosphoinositide dependent signalling – Lipid phosphatases | 2FVV/2Q9P |
MIOX | Inositol oxygenase | Q9UGB7 | 38-285 | Phosphoinositide dependent signalling – Others | 2IBN |
SNX17 | Sorting nexin-17, PX domain | Q15036 | 1-108 | Phosphoinositide dependent signalling – Others | 3FOG |
IMPA2 | Inositol monophosphatase 2 | O14732 | 16-288 | Phosphoinositide dependent signalling – PIP-Phosphatases | 2FVZ |
INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase | P32019 | 339-643 | Phosphoinositide dependent signalling – PIP-Phosphatases | 3MTC |
INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase | P32019 | 341-646 | Phosphoinositide dependent signalling – PIP-Phosphatases | 3N9V |
INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV | Q9NRR6 | 275-623 | Phosphoinositide dependent signalling – PIP-Phosphatases | 2XSW |
INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | O15357 | 419-732 | Phosphoinositide dependent signalling – PIP-Phosphatases | 3NR8 |
DNPEP | Aspartyl aminopeptidase | Q9ULA0 | 1-478 | Protease-Other | 3L6S (4DYO) |
G3BP1 | Ras GTPase-activating protein-binding protein 1, NTF2 domain | Q13283 | 1-139 | Receptor Signaling Domains | 3Q90 |
SKIL | Ski-like protein | P12757 | 137-238 | Receptor Signaling Domains | 3EQ5 |
TLR10 | Toll-like receptor 10, TIR domain | Q9BXR5 | 622-776 | Receptor Signaling Domains | 2J67 |
NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 | O43809 | 21-227 | RNA processing | 3N9U |
LASP1 | LIM and SH3 domain protein 1, SH3 domain | Q14847 | 202-261 | SH3 domain | 3I35 |
SOCS6 | Suppressor of cytokine signaling 6, SH2 domain | O14544 | 361-499 | SOCS-box-containing | 2VIF |
SPSB1 | SPRY domain-containing SOCS box protein 1 | Q96BD6 | 24-233 | SOCS-box-containing | 2JK9 |
SPSB2 | SPRY domain-containing SOCS box protein 2 | Q99619 | 26-219 | SOCS-box-containing | 3EMW |
SPSB4 | SPRY domain-containing SOCS box protein 4 | Q96A44 | 28-233 | SOCS-box-containing | 2V24 |
AMPH | Amphiphysin | P49418 | 34-236 | To be assigned | 3SOG |
ENO3 | Beta-enolase | P13929 | 1-434 | To be assigned | 2XSX |
GYG1 | Glycogenin 1 | P46976 | 1-262 | To be assigned | 3Q4S |
HBP1 | HMG-box transcription factor 1 | O60381 | 206-342 | To be assigned | 3QVE |
MACROH2A2 | Core histone macro-H2A.2 | Q9P0M6 | 177-369 | To be assigned | 2XD7 |
EBF1 | Transcription factor COE1, DNA binding domain | Q9UH73 | 10-250 | Transcription-Factor | 3LYR |
EBF1 | Transcription factor COE1, IPT/TIG domain | Q9UH73 | 258-351 | Transcription-Factor | 3MQI |
EBF3 | Transcription factor COE3, IPT/TIG domain | Q9H4W6 | 261-395 | Transcription-Factor | 3MUJ |
EBF3 | Transcription factor COE3, IPT/TIG domain, helix-loop-helix domain | Q9H4W6 | 261-415 | Transcription-Factor | 3N50 |
ACAA1 | 3-ketoacyl-CoA thiolase, peroxisomal | P09110 | 30-424 | Transferase | 2IIK |
FDPS | Farnesyl pyrophosphate synthase | P14324 | 67-419 | Transferase | 2QIS |
GGPS1 | Geranylgeranyl pyrophosphate synthase | O95749 | 1-300 | Transferase | 2Q80 |
GOT1 | Aspartate aminotransferase 1, cytoplasmic | P17174 | 14-412 | Transferase | 3II0 |
HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | Q01581 | 16-470 | Transferase | 2P8U |
HMGCS2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | Transferase | 2V4W | ||
MAT1A | Methionine adenosyltransferase I, alpha | Q00266 | 16-395 | Transferase | 2OBV |
MAT2A | Methionine adenosyltransferase II, alpha | P31153 | 1-395 | Transferase | 2P02 |
MCAT | Malonyl-CoA:acyl carrier protein transacylase (malonyltransferase) [isoform 1] | Q8IVS2 | 60-375 | Transferase | 2C2N |
OXCT1 | 3-oxoacid CoA transferase | P55809 | 40-520 | Transferase | 3DLX |
OXSM | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial | Q9NWU1 | 39-459 | Transferase | 2C9H |
TKT | Transketolase | P29401 | 10-620 | Transferase | 3OOY |
TGM1 | Protein-glutamine gamma-glutamyltransferase K, Ig domain | P22735 | 693-787 | Transglutaminase | 2XZZ |
ARNT | Aryl hydrocarbon receptor nuclear translocator | P27540 | 356-470 | Various other targets | |
BAK1 | Bcl-2 homologous antagonist/killer, mitochondrial apoptosis regulator | Q16611 | 21-190 | Various other targets | 2JCN |
BCL2A1 | Bcl-2-related protein A1 | Q16548 | 1-149 | Various other targets | 2VM6 |
EPAS1 | Endothelial PAS domain-containing protein 1 | Q99814 | 239-350 | Various other targets | |
GLS | Glutaminase kidney isoform, mitochondrial | O94925 | 221-533 | Various other targets | 3CZD |
NT5C2 | Cytosolic purine 5′-nucleotidase | P49902 | 1-536 | Various other targets | 2J2C/2JC9/2JCM |
NT5C3 | Cytosolic 5′-nucleotidase 3A | Q9H0P0 | 64-336 | Various other targets | 2CN1/2JGA/2VKQ |
NUDT | Oxidized purine nucleoside triphosphate hydrolase | P36639 | 42-197 | Various other targets | |
SYN3 | Synapsin 3 | O14994 | 76-417 | Vesicle-Transport | 2P0A |
ZFYVE16 | Zinc finger FYVE domain-containing protein 16, FYVE zinc finger domain | Q7Z3T8 | 733-820 | zinc finger domain | 3T7L |
PKM2 | Pyruvate kinase isozymes | P14618 | 3-530 |