Gene-to-Structure and FastLane™ Structures

SARomics Biostructures' services include:
• Gene-to-Structure: expression, purification, crystallization and structure determination
• Co-crystallization of a Protein-ligand complex and X-ray structure determination
• Protein characterization (folding, solubility, aggregation, thermo-stability, etc.)

SARomics Biostructures' FastLane™ off-the-shelf structure library includes around 180 kinases, phosphatases, epigenetic targets and other proteins. The crystal structures of these proteins in complex with your ligand/ligands can be delivered within 4 to 12 weeks. Our strategic location in close vicinity to the new Swedish synchrotron MAX IV in Lund provides us with quick access to beamlines, minimizing the need for crystal transportation to remote synchrotrons and allowing us to offer quick services at highly competitive prices. Please view below the lists of available structures or contact us for the discussion of your project.

CK2 kinase 3D structure
Vps34 kinase 3D structure
PFKFB3 3D structure
HSP90 3D structure
Cathepsin C 3D structure
My Image
ATAD2 Bromodomain 3D structure
Aldose reductase 3D structure
PDE4D2 3D structure
M. tuberculosis beta-lactamase (BlaC) 3D structure
M. tuberculosis beta-lactamase (BlaC) 3D structure
M. tuberculosis beta-lactamase (BlaC) 3D structure

Our premium class of FastLane™ structures includes purified proteins stored in our lab and ready to be co-crystallized with customer's compounds. Delivery time 2 to 6 weeks. In most cases the ability to obtain co-crystal structures with ligands has been demonstrated. Please click the link below for the full list.

  • Premium FastLane™ Structures

    AR or Aldose reductase (a.a. 1-316)

    ATAD2A - Bromodomain, ATPase family AAA domain-containing protein 2 (a.a. 981-1108)

    ATAD2B - Bromodomain, ATPase family AAA domain-containing protein 2B, (a.a. 952-1086)

    BCAT2 - Branched-chain-amino-acid aminotransferase, mitochondrial

    Beta-lactamase - BlaC or Beta-lactamase (M. tuberculosis)

    BTK kinase - Tyrosine-protein kinase BTK

    Cathepsin C - DPPI or Dipeptidyl peptidase 1

    CLK3 - Dual specificity protein kinase CLK3

    CK2 kinase - Casein kinase II subunit alpha

    DAPK3 kinase - Death-associated protein kinase 3

    DHODH - Dihydroorotate dehydrogenase (human)

    EphA7 kinase - Ephrin type-A receptor 7

    Gal-3C - Galectin-3

    GMPR2 - GMP reductase 2

    HSP90 - Heat shock protein HSP 90-alpha

    IL-17A - Interleukin-17A

    JMJD2C - KDM4C or Lysine-specific demethylase 4C (a.a. 1-347)

    LDHA - L-lactate dehydrogenase A chain (rabbit)

    LSD1 - KDM1A or Lysine-specific histone demethylase 1A

    PIP4K2A kinase - Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

    PDE4D - cAMP-specific 3',5'-cyclic phosphodiesterase 4D

    PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

    PLK4 kinase - Serine/threonine-protein kinase PLK4

    PTP1B - PTPN1 or Tyrosine-protein phosphatase non-receptor type 1

    ROR-gamma - Nuclear receptor ROR-gamma

    S100A4 - Mts1 or Protein S100-A4

    S100A9 - MRP14 or Protein S100-A9

    S100A12 - Protein S100-A12

    STK10 kinase - LOK or Serine/threonine-protein kinase 10

    STK17B kinase - DRAK2 or Serine/threonine-protein kinase 17B

    Thrombin - human alpha thrombin

    TIM3 - Hepatitis A virus cellular receptor 2

    TNF-alpha - Tumor necrosis factor

    Tubulin - Pig tubulin alpha-1A

    USP8 - Ubiquitin carboxyl-terminal hydrolase 8

FastLane™ Structures

Our library of FastLane™ (off-the-shelf) structures includes about 150 proteins ready to be expressed, purified and crystallized according to existing verified protocols. The Library currently includes more than 50 kinases, a large collection of phosphatases, more than 40 epigenetic targets and other proteins. Crystal structures of ligand complexes can be delivered within 6 to 12 weeks.

You may also be interested in our drug discovery platform, which uses fragment screening and fragment-based drug discovery!